Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 12/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 12/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 12/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 12/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 12/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 12/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.44 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | MET | P08581 | 3/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL987229 | 1.00 | PSEN1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13731462 | 1.00 | PSEN1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27952707 | 0.87 | MET (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL984704 | 0.84 | MET (0.47) | KCNH2KCNN4MET | |
| SCHEMBL986014 | 0.80 | MET (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL986614 | 0.80 | MET (0.38) | KCNN4MET | |
| SCHEMBL986593 | 0.80 | KCNN4 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13593260 | 0.80 | KCNN4 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL986932 | 0.79 | MET (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL985713 | 0.79 | MET (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232406-B2 | c-MET protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-31 | — | — | US | claimed |
| US-20110059936-A1 | C-MET PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-03-10 | — | — | US | claimed |
| US-7872031-B2 | c-MET protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-01-18 | — | — | US | claimed |
| EP-2004625-B1 | C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | VERTEX PHARMA (US) | 2009-12-30 | — | — | EP | claimed |
| US-20070254868-A1 | C-MET protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-11-01 | — | — | US | claimed |
| US-10059704-B2 | 1,4-disubstituted 1,2,3-triazoles, methods for preparing same, and diagnostic and therapeutic uses thereof | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2018-08-28 | — | — | US | disclosed |
| US-20140030191-A1 | 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES, METHODS FOR PREPARING SAME, AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2014-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140030191-A1 | 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES, METHODS FOR PREPARING SAME, AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF | CYP3A43, NAT1, UGT1A1 | PSEN1 4740/4885PSEN2 4752/4885APH1B 4056/4885 |
| US-10059704-B2 | 1,4-disubstituted 1,2,3-triazoles, methods for preparing same, and diagnostic and therapeutic uses thereof | CYP3A43, NAT1, UGT1A1 | PSEN1 4740/4885PSEN2 4752/4885APH1B 4056/4885 |
| US-20110059936-A1 | C-MET PROTEIN KINASE INHIBITORS | MET, PRKCH, ABL1 | PSEN1 1801/4885PSEN2 1476/4885APH1B 2640/4885 |
| US-20070254868-A1 | C-MET protein kinase inhibitors | MET, PRKCH, ABL1 | PSEN1 1801/4885PSEN2 1476/4885APH1B 2640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.