Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.64 |
| ▸ | TOP2A | P11388 | 6/20 | 0.62 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | ALB | P02768 | 1/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.62 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | TUBB | P07437 | 1/20 | 0.61 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.61 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.61 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.61 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.61 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.61 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.61 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9872786 | 0.89 | KDM4E (0.64) | KDM4EKMT2AAADATTOP2ATOP2B | |
| SCHEMBL9874554 | 0.86 | KDM4E (0.67) | KDM4EKMT2AAADATTOP2ATOP2B | |
| SCHEMBL10578766 | 0.86 | KDM4E (0.62) | KDM4EKMT2AAADATTOP2ATOP2B | |
| SCHEMBL10577413 | 0.85 | KDM4E (0.65) | KDM4EKMT2AAADATTOP2ATOP2B | |
| SCHEMBL9748666 | 0.84 | KDM4E (0.56) | KDM4EKMT2AAADATTOP2ATOP2B | |
| SCHEMBL9748689 | 0.84 | KDM4E (0.56) | KDM4EKMT2AAADATTOP2ATOP2B | |
| SCHEMBL25430297 | 0.83 | KDM4E (0.73) | KDM4EKMT2AAADATTOP2ATOP2B | |
| SCHEMBL31256899 | 0.83 | KDM4E (0.73) | KDM4EKMT2AAADATTOP2ATOP2B | |
| SCHEMBL9304083 | 0.83 | KDM4E (0.73) | KDM4EKMT2AAADATTOP2ATOP2B | |
| SCHEMBL9873849 | 0.83 | KDM4E (0.57) | KDM4EKMT2AAADATTOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4990508-A | Reduced side effects | TOYAMA CHEMICAL CO., LTD. (JP) | 1991-02-05 | — | — | US | disclosed |