Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9873855 | 1.00 | ALDH1A1 (0.42) | ALDH1A1KDM4EPSEN1PSEN2APH1B | |
| SCHEMBL9874618 | 0.97 | KDM4E (0.39) | ALDH1A1KDM4EPSEN1PSEN2APH1B | |
| SCHEMBL66816 | 0.89 | ATM (0.39) | ALDH1A1KDM4EPSEN1PSEN2APH1B | |
| SCHEMBL9871837 | 0.89 | ATM (0.39) | ALDH1A1KDM4EPSEN1PSEN2APH1B | |
| SCHEMBL3815673 | 0.86 | SSTR4 (0.39) | ALDH1A1KDM4ECHRNB2CHRNA4CHRNB4 | |
| SCHEMBL7502450 | 0.79 | BTK (0.43) | SSTR4 | |
| SCHEMBL7502974 | 0.79 | BTK (0.43) | SSTR4 | |
| SCHEMBL6645129 | 0.79 | BTK (0.43) | SSTR4 | |
| SCHEMBL27782957 | 0.78 | PSEN1 (0.46) | ALDH1A1KDM4EPSEN1PSEN2APH1B | |
| SCHEMBL7735033 | 0.78 | PSEN1 (0.46) | ALDH1A1KDM4EPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5017708-A | Azabicycloalkanes | SHIONOGI & CO., LTD. (JP) | 1991-05-21 | — | — | US | claimed |
| EP-0359172-A1 | Azabicycloalkanes | SHIONOGI & CO., LTD. (JP) | 1990-03-21 | — | — | EP | claimed |
| EP-0359172-A1 | Azabicycloalkanes | SHIONOGI & CO., LTD. (JP) | 1990-03-21 | — | — | EP | disclosed |