Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.65 |
| ▸ | CA2 | P00918 | 3/20 | 0.62 |
| ▸ | CA7 | P43166 | 3/20 | 0.62 |
| ▸ | CA9 | Q16790 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | AGER | Q15109 | 1/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397022 | 0.87 | CA1 (0.78) | CA1CA2CA7CA9MAPK1 | |
| SCHEMBL12601486 | 0.83 | CA1 (0.56) | CA1CA2CA7CA9MAPK1 | |
| SCHEMBL7153591 | 0.80 | CA1 (0.76) | CA1CA2CA7CA9MAPK1 | |
| SCHEMBL9661261 | 0.79 | CA1 (0.66) | CA1CA2CA7CA9MAPK1 | |
| SCHEMBL5333780 | 0.79 | CA1 (0.66) | CA1CA2CA7CA9MAPK1 | |
| SCHEMBL15764380 | 0.79 | CA1 (0.66) | CA1CA2CA7CA9MAPK1 | |
| SCHEMBL23258692 | 0.78 | CA1 (0.70) | CA1CA2CA7CA9MAPK1 | |
| SCHEMBL508126 | 0.78 | CA1 (0.70) | CA1CA2CA7CA9MAPK1 | |
| SCHEMBL16269805 | 0.78 | CA1 (0.70) | CA1CA2CA7CA9MAPK1 | |
| SCHEMBL122306 | 0.78 | CA1 (0.70) | CA1CA2CA7CA9MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049694-A | Cardiovascular disorders | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-09-17 | — | — | US | disclosed |
| EP-0359335-A2 | Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance | CEDONA PHARMACEUTICALS B.V. (NL) | 1990-03-21 | — | — | EP | disclosed |