Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.69 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.69 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 11/20 | 0.55 |
| ▸ | TOP2A | P11388 | 1/20 | 0.53 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10701879 | 0.89 | POLB (0.71) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL8201556 | 0.85 | CACNA1F (0.78) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL9501954 | 0.84 | KCNH2 (0.58) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL8922019 | 0.84 | POLB (0.72) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL10684653 | 0.84 | KCNH2 (0.72) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL10412149 | 0.83 | CACNA1F (0.71) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL10686828 | 0.83 | CACNA1F (0.74) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL10108762 | 0.83 | CACNA1F (0.74) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL10123852 | 0.83 | CACNA1F (0.74) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL12665464 | 0.83 | KCNH2 (0.74) | CACNA1FPOLBMAPK1CACNA1DKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221463-B1 | QUINOLINE DERIVATIVES AND PROCESSES FOR PREPARATION THEREOF | Dainippon Pharmaceutical Co., Ltd. (JP) | 1991-08-14 | — | — | EP | disclosed |