Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROS1 | P08922 | 1/20 | 0.44 |
| ▸ | RORB | Q92753 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.36 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.36 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988801 | 0.83 | MAPT (0.40) | ROS1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL12680021 | 0.76 | CYP1A1 (0.43) | ROS1MAPK14CYP3A4CYP1A1CYP1A2 | |
| SCHEMBL989130 | 0.74 | CCNT1 (0.45) | ROS1MAPK14CYP3A4CYP1A1CYP1A2 | |
| SCHEMBL3921214 | 0.74 | BRAF (0.46) | MAPK14 | |
| SCHEMBL988405 | 0.73 | ROS1 (0.52) | ROS1FLT3DYRK1AGSK3BDYRK2 | |
| SCHEMBL2049976 | 0.69 | HSD17B1 (0.39) | RORBRORCIDO1PARP10PARP11 | |
| SCHEMBL988741 | 0.69 | FLT3 (0.69) | ROS1RORBRORCFLT3DYRK1A | |
| SCHEMBL5256574 | 0.68 | MAPK14 (0.49) | MAPK14DYRK1AGSK3BPIM1DYRK2 | |
| SCHEMBL3912471 | 0.68 | CCNT1 (0.39) | MAPK14CYP3A4CYP1A1CYP1A2CYP2E1 | |
| SCHEMBL3917686 | 0.67 | CCNT1 (0.44) | MAPK14CYP3A4CYP1A1CYP1A2CYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110015395-A1 | PYRAZOLE COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST ROS KINASE | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-01-20 | — | — | US | claimed |
| US-8273880-B2 | Pyrazole compounds with inhibitory activity against ROS kinase | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-09-25 | — | — | US | disclosed |
| US-8273880-B2 | Pyrazole compounds with inhibitory activity against ROS kinase | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-09-25 | — | — | US | disclosed |
| US-8273880-B2 | Pyrazole compounds with inhibitory activity against ROS kinase | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-09-25 | — | — | US | disclosed |
| US-20110015395-A1 | PYRAZOLE COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST ROS KINASE | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-01-20 | — | — | US | disclosed |
| US-20110015395-A1 | PYRAZOLE COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST ROS KINASE | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-01-20 | — | — | US | disclosed |
| US-20110015395-A1 | PYRAZOLE COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST ROS KINASE | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015395-A1 | PYRAZOLE COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST ROS KINASE | ROS1, PDPK1, MAP3K19 | ROS1 1/4885RORB 745/4885RORC 726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.