Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 6/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 5/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9871710 | 0.94 | AGTR1 (0.42) | AGTR1AGTR2GRM2KMT2AKDM4E | |
| SCHEMBL9874210 | 0.93 | AGTR1 (0.42) | AGTR1AGTR2GRM2KMT2AKDM4E | |
| SCHEMBL9872125 | 0.91 | AGTR1 (0.40) | AGTR1AGTR2GRM2KMT2AKDM4E | |
| SCHEMBL9873884 | 0.91 | AGTR1 (0.40) | AGTR1AGTR2GRM2KMT2AKDM4E | |
| SCHEMBL9872996 | 0.90 | AGTR1 (0.41) | AGTR1AGTR2KMT2AKDM4EMEN1 | |
| SCHEMBL9873145 | 0.89 | AGTR1 (0.39) | AGTR1AGTR2KMT2AKDM4EMEN1 | |
| SCHEMBL9872036 | 0.89 | AGTR1 (0.41) | AGTR1AGTR2TLR7 | |
| SCHEMBL9873995 | 0.89 | AGTR1 (0.41) | AGTR1AGTR2GRM2KMT2AKDM4E | |
| SCHEMBL9873587 | 0.88 | TLR7 (0.40) | AGTR1AGTR2KMT2AKDM4EMEN1 | |
| SCHEMBL9873108 | 0.88 | AGTR1 (0.38) | AGTR1AGTR2GRM2KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019715-A1 | 1H-SUBSTITUTED-IMIDAZO[4,5-d]PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1991-12-26 | — | — | WO | disclosed |