Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3874745 | 0.77 | HTR2A (0.61) | HTR2AKDM4ECYP2D6LMNATP53 | |
| SCHEMBL8957419 | 0.77 | HTR2A (0.46) | HTR2AKDM4ECYP2D6LMNATP53 | |
| SCHEMBL9205280 | 0.72 | HTR2A (0.61) | HTR2AKDM4ECYP2D6LMNATP53 | |
| SCHEMBL8256345 | 0.69 | HTR2A (0.69) | HTR2AKDM4ECYP2D6LMNATP53 | |
| SCHEMBL2231461 | 0.68 | TDO2 (0.61) | HTR2AKDM4ECYP2D6LMNATP53 | |
| SCHEMBL30413587 | 0.68 | TDO2 (0.61) | HTR2AKDM4ECYP2D6LMNATP53 | |
| SCHEMBL13393720 | 0.67 | HTR2A (0.49) | HTR2AKDM4ECYP2D6LMNATP53 | |
| SCHEMBL13248564 | 0.66 | HTR2A (0.57) | HTR2AKDM4ECYP2D6LMNATP53 | |
| SCHEMBL11430690 | 0.66 | HTR2A (0.61) | HTR2AKDM4ECYP2D6LMNATP53 | |
| SCHEMBL11726371 | 0.66 | HTR2A (0.64) | HTR2AKDM4ECYP2D6LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049694-A | Cardiovascular disorders | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-09-17 | — | — | US | disclosed |
| EP-0359335-A2 | Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance | CEDONA PHARMACEUTICALS B.V. (NL) | 1990-03-21 | — | — | EP | disclosed |