Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 10/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 2/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7577816 | 0.92 | ADRB2 (0.51) | ADRB2STAT3HTTGSK3BMEN1 | |
| SCHEMBL1345146 | 0.87 | STAT3 (0.65) | ADRB2STAT3HTTGSK3BMEN1 | |
| SCHEMBL8111555 | 0.85 | STAT3 (0.56) | ADRB2STAT3HTTGSK3BMEN1 | |
| SCHEMBL7111565 | 0.85 | ADRB2 (0.50) | ADRB2STAT3HTTGSK3BMEN1 | |
| SCHEMBL9876052 | 0.84 | MEN1 (0.49) | ADRB2STAT3HTTGSK3BMEN1 | |
| SCHEMBL10594730 | 0.84 | STAT3 (0.55) | ADRB2STAT3HTTGSK3BMEN1 | |
| SCHEMBL8129186 | 0.84 | STAT3 (0.58) | ADRB2STAT3HTTGSK3BMEN1 | |
| SCHEMBL7578035 | 0.83 | ADRB2 (0.51) | ADRB2STAT3HTTGSK3BMEN1 | |
| SCHEMBL8851823 | 0.83 | STAT3 (0.54) | ADRB2STAT3HTTGSK3BMEN1 | |
| SCHEMBL8111795 | 0.83 | STAT3 (0.54) | ADRB2STAT3HTTGSK3BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221463-B1 | QUINOLINE DERIVATIVES AND PROCESSES FOR PREPARATION THEREOF | Dainippon Pharmaceutical Co., Ltd. (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4886810-A | ANTIBACTERIAL | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1989-12-12 | — | — | US | disclosed |
| US-4795751-A | 5-substituted-6,8-difluoroquinolines useful as antibacterial agents | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1989-01-03 | — | — | US | disclosed |
| EP-0242789-A2 | Novel quinoline derivates and processes for preparation thereof | Dainippon Pharmaceutical Co., Ltd. (JP) | 1987-10-28 | — | — | EP | disclosed |
| EP-0221463-A2 | Quinoline derivatives and processes for preparation thereof | Dainippon Pharmaceutical Co., Ltd. (JP) | 1987-05-13 | — | — | EP | disclosed |