Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.53 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9875509 | 1.00 | NR1I2 (0.60) | NR1I2MAPTCYP1A2ADORA3CYP2C9 | |
| SCHEMBL9875988 | 0.87 | NR1I2 (0.61) | NR1I2MAPTCYP1A2ADORA3CYP2C9 | |
| SCHEMBL9874899 | 0.87 | NR1I2 (0.61) | NR1I2MAPTCYP1A2ADORA3CYP2C9 | |
| SCHEMBL9806914 | 0.87 | NR1I2 (0.76) | NR1I2MAPTCYP1A2ADORA3CYP2C9 | |
| SCHEMBL10584053 | 0.86 | NR1I2 (0.55) | NR1I2MAPTCYP1A2ADORA3CYP2C9 | |
| SCHEMBL10517644 | 0.86 | NR1I2 (0.54) | NR1I2MAPTCYP1A2ADORA3CYP2C9 | |
| SCHEMBL9875316 | 0.86 | TSHR (0.62) | NR1I2MAPTCYP1A2ADORA3CYP2C9 | |
| SCHEMBL9874889 | 0.85 | NR1I2 (0.58) | NR1I2MAPTCYP1A2ADORA3CYP2C9 | |
| SCHEMBL9875437 | 0.84 | MAPT (0.58) | NR1I2MAPTCYP1A2ADORA3CYP2C9 | |
| SCHEMBL9875432 | 0.84 | MAPT (0.58) | NR1I2MAPTCYP1A2ADORA3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5008279-A | Circulation-active fluoromethoxyphenyl dihydropyridine compounds | BAYER AKTIENGESELLSCHAFT (DE) | 1991-04-16 | — | — | US | disclosed |
| CN-1040192-A | New fluorine methoxyphenyl dihydropyridine, its preparation method and the application aspect medicine | BAYER AG (DE) | 1990-03-07 | — | — | CN | disclosed |
| EP-0315018-A2 | Fluoromethoxyphenyl-dihydropyridines, process for their preparation and their use in drugs | BAYER AG (DE) | 1989-05-10 | — | — | EP | disclosed |
| US-4764516-A | Mixtures of optically active nitrodihydropyridines active on the circulatory system | BAYER AKTIENGESELLSCHAFT (DE) | 1988-08-16 | — | — | US | disclosed |