SCHEMBL987568

SCHEMBL987568

Cn1c(=O)[nH]c(N2CCC[C@@H](N)C2)c(Cc2cc(F)ccc2C#N)c1=O

nearest known ligand 0.59

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 20/20 0.59
CYP1A2 P05177 1/20 0.55
CYP3A4 P08684 1/20 0.55
CYP2D6 P10635 1/20 0.55
KCNH2 Q12809 1/20 0.51
FAP Q12884 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3663764 0.87 DPP4 (0.59) DPP4
Hydrochloric Acid SCHEMBL18209332 0.86 DPP4 (0.58) DPP4
SCHEMBL4212805 0.82 DPP4 (0.61) DPP4CYP1A2CYP3A4CYP2D6KCNH2
SCHEMBL8774874 0.77 DPP4 (0.77) DPP4CYP1A2CYP3A4CYP2D6
SCHEMBL27964065 0.74 DPP4 (0.86) DPP4CYP1A2CYP3A4CYP2D6
Trelagliptin SCHEMBL175727 0.74 DPP4 (1.00) DPP4CYP1A2CYP3A4CYP2D6
Trelagliptin SCHEMBL29349599 0.74 DPP4 (1.00) DPP4CYP1A2CYP3A4CYP2D6
Trelagliptin SCHEMBL175726 0.74 DPP4 (1.00) DPP4CYP1A2CYP3A4CYP2D6
SCHEMBL6507784 0.74 DPP4 (0.59) DPP4KCNH2FAP
SCHEMBL6511158 0.73 DPP4 (0.56) DPP4KCNH2FAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2854772-A1 SOLID PREPARATION Takeda Pharmaceutical Company Limited (JP) 2015-04-08 EP claimed
WO-2013183784-A1 SOLID PREPARATION TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-12-12 WO claimed
WO-2011005929-A1 PIPERIDINE DERIVATIVE AND ITS USE FOR THE TREATMENT OF DIABETS AND OBESITY ARENA PHARMACEUTICALS, INC. (US) 2011-01-13 WO claimed
EP-2120885-A2 SOLID PREPARATION COMPRISING 2-[[6-[(3R)-3-AMINO-1-PIPERIDINYL]-3,4-DIHYDRO-3-METHYL-2,4-DIOXO-1(2H)-PYRIMIDINYL]METHYL]-4-FLUOROBENZONITRILE Takeda Pharmaceutical Company Limited (JP) 2009-11-25 EP claimed
WO-2008114800-A2 SOLID PREPARATION COMPRISING 2- [ [6- [ (3R) -3-AMINO-1-PIPERIDINYL] -3, 4-DIHYDRO-3-METHYL-2, 4-DIOXO-1 (2H) -PYRIMIDINYL] METHYL] -4-FLUOROBENZONITRILE TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-09-25 WO claimed
EP-2675774-A1 PRODUCTION METHOD OF OPTICALLY ACTIVE DIHYDROBENZOFURAN DERIVATIVE Takeda Pharmaceutical Company Limited (JP) 2013-12-25 EP disclosed
WO-2012111849-A1 PRODUCTION METHOD OF OPTICALLY ACTIVE DIHYDROBENZOFURAN DERIVATIVE TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2012-08-23 WO disclosed
EP-2120885-A2 SOLID PREPARATION COMPRISING 2-[[6-[(3R)-3-AMINO-1-PIPERIDINYL]-3,4-DIHYDRO-3-METHYL-2,4-DIOXO-1(2H)-PYRIMIDINYL]METHYL]-4-FLUOROBENZONITRILE Takeda Pharmaceutical Company Limited (JP) 2009-11-25 EP disclosed
EP-2041123-A2 FUSED CYCLIC COMPOUNDS Takeda Pharmaceutical Company Limited (JP) 2009-04-01 EP disclosed
WO-2008114800-A2 SOLID PREPARATION COMPRISING 2- [ [6- [ (3R) -3-AMINO-1-PIPERIDINYL] -3, 4-DIHYDRO-3-METHYL-2, 4-DIOXO-1 (2H) -PYRIMIDINYL] METHYL] -4-FLUOROBENZONITRILE TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-09-25 WO disclosed
WO-2008001931-A2 FUSED CYCLIC COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-01-03 WO disclosed