Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.59 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876035 | 0.86 | REN (0.59) | REN | |
| SCHEMBL10867564 | 0.85 | REN (0.55) | REN | |
| Hydrochloric Acid SCHEMBL9876270 | 0.85 | ANPEP (0.51) | RENSIRT2SIRT1 | |
| SCHEMBL22834040 | 0.83 | MAPT (0.59) | — | |
| SCHEMBL22834041 | 0.83 | MAPT (0.59) | — | |
| SCHEMBL22834242 | 0.83 | KLK7 (0.54) | — | |
| SCHEMBL22834240 | 0.83 | KLK7 (0.54) | — | |
| SCHEMBL18942686 | 0.81 | KLK7 (0.65) | SIRT2SIRT1 | |
| SCHEMBL24130643 | 0.81 | KLK7 (0.59) | SIRT2SIRT1 | |
| SCHEMBL24130639 | 0.81 | KLK7 (0.59) | SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992562-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4948913-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1990-08-14 | — | — | US | disclosed |
| US-4729985-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1988-03-08 | — | — | US | disclosed |