Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873359 | 0.79 | CHRNB2 (0.41) | LMNACHRNB2SLC6A2CHRNB4CHRNA3 | |
| SCHEMBL9876612 | 0.78 | SLC6A2 (0.35) | POLBCHRNB2SLC6A2CHRNB4CHRNA3 | |
| SCHEMBL27997710 | 0.76 | CHRNB2 (0.39) | LMNACHRNB2SLC6A2CHRNB4CHRNA3 | |
| SCHEMBL9709000 | 0.76 | AKR1C1 (0.40) | LMNAMAPK1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL1664714 | 0.74 | TSHR (0.47) | LMNAMAPK1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL14306895 | 0.71 | CYP1A2 (0.42) | MAPK1CHRNB2SLC6A2CHRNB4CHRNA3 | |
| SCHEMBL6493723 | 0.71 | MEN1 (0.40) | POLBCHRNB2SLC6A2CHRNB4CHRNA3 | |
| SCHEMBL5616835 | 0.71 | CYP1A2 (0.42) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL6493726 | 0.71 | MEN1 (0.40) | POLBCHRNB2SLC6A2CHRNB4CHRNA3 | |
| SCHEMBL9315392 | 0.69 | CHRNB2 (0.44) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254078-B1 | PYRAN DERIVATIVES | BASF Aktiengesellschaft (DE) | 1991-02-06 | — | — | EP | disclosed |
| EP-0254078-A1 | Pyran derivatives | BASF Aktiengesellschaft (DE) | 1988-01-27 | — | — | EP | disclosed |