Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 14/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357503 | 0.81 | REN (0.52) | REN | |
| SCHEMBL10673839 | 0.81 | REN (0.46) | RENCTSK | |
| SCHEMBL7360605 | 0.81 | REN (0.46) | RENCTSK | |
| SCHEMBL10675537 | 0.81 | REN (0.46) | RENCTSK | |
| SCHEMBL9876267 | 0.80 | KLK5 (0.41) | RENCTSK | |
| SCHEMBL10625927 | 0.79 | REN (0.46) | RENCTSK | |
| SCHEMBL9876626 | 0.76 | REN (0.56) | REN | |
| SCHEMBL10458260 | 0.76 | REN (0.50) | REN | |
| SCHEMBL9876624 | 0.75 | REN (0.49) | REN | |
| SCHEMBL9876274 | 0.75 | REN (0.49) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992562-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4948913-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1990-08-14 | — | — | US | disclosed |
| US-4729985-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1988-03-08 | — | — | US | disclosed |
| EP-0212903-A2 | Polypeptide derivatives containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1987-03-04 | — | — | EP | disclosed |