Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KDM5A | P29375 | 2/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6624817 | 0.88 | KDM4E (0.49) | KDM4ESMN1; SMN2KMT2AGAAHTT | |
| SCHEMBL6626868 | 0.88 | KDM4E (0.49) | KDM4ESMN1; SMN2KMT2AGAAHTT | |
| SCHEMBL6628654 | 0.86 | KDM4E (0.48) | KDM4ESMN1; SMN2KMT2AGAAHTT | |
| SCHEMBL6628338 | 0.86 | KDM4E (0.50) | KDM4ESMN1; SMN2KMT2AGAAHTT | |
| SCHEMBL6626852 | 0.86 | KDM4E (0.50) | KDM4ESMN1; SMN2KMT2AGAAHTT | |
| SCHEMBL6625974 | 0.86 | KDM4E (0.53) | KDM4ESMN1; SMN2KMT2AGAAHTT | |
| SCHEMBL6622385 | 0.86 | KDM4E (0.48) | KDM4ESMN1; SMN2KMT2AGAAHTT | |
| SCHEMBL6624437 | 0.85 | KDM4E (0.47) | KDM4ESMN1; SMN2KMT2AGAAHTT | |
| SCHEMBL6623409 | 0.85 | KDM4E (0.49) | KDM4ESMN1; SMN2KMT2AGAAHTT | |
| SCHEMBL6622411 | 0.85 | ALDH1A1 (0.48) | KDM4ESMN1; SMN2KMT2AGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992442-A | Bronchodilator agents | POLA CHEMICAL INDUSTRIES INC., JAPAN (JP) | 1991-02-12 | — | — | US | disclosed |
| EP-0369145-A2 | Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidine derivatives and medicines comprising the same | POLA CHEMICAL INDUSTRIES INC., JAPAN (JP) | 1990-05-23 | — | — | EP | disclosed |