Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11624710 | 0.87 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2AMEN1KDM4EHPGD | |
| SCHEMBL11620869 | 0.86 | SMN1; SMN2 (0.41) | SMN1; SMN2KMT2AMEN1KDM4EHPGD | |
| SCHEMBL11624052 | 0.84 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2AMEN1KDM4EHPGD | |
| SCHEMBL11620762 | 0.84 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2AMEN1KDM4EHPGD | |
| SCHEMBL11621488 | 0.84 | SMN1; SMN2 (0.39) | SMN1; SMN2KMT2AMEN1KDM4EHPGD | |
| SCHEMBL11622171 | 0.83 | SMN1; SMN2 (0.42) | SMN1; SMN2KMT2AMEN1CKS1BSKP1 | |
| SCHEMBL11625281 | 0.82 | SMN1; SMN2 (0.39) | SMN1; SMN2KMT2AMEN1KDM4EHPGD | |
| SCHEMBL11623034 | 0.82 | SMN1; SMN2 (0.39) | SMN1; SMN2KMT2AMEN1AURKAKDM4E | |
| SCHEMBL11620331 | 0.82 | SMN1; SMN2 (0.38) | PTGIRSMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL11618350 | 0.81 | TSHR (0.48) | SMN1; SMN2KMT2AMEN1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988725-A | Cardiovascular disorders, antiarrhythmia agents | STERLING DRUG INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4925857-A | Pyridinyl-1H-pyrazole-1-alkanamides as antiarrhythmic agents | STERLING DRUG INC. (US) | 1990-05-15 | — | — | US | disclosed |
| US-4916150-A | 1H-pyrazole-1-alkanamines antiarrhythmic compositions and use | STERLING DRUG INC. (US) | 1990-04-10 | — | — | US | disclosed |
| US-4898880-A | N-(heterocycle)alkyl)-1H-pyrazole-1-alkanamides as antiarrhythmic agents, compositions and use | STERLING DRUG INC. (US) | 1990-02-06 | — | — | US | disclosed |
| US-4870095-A | 1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use | STERLING DRUG, INC. (US) | 1989-09-26 | — | — | US | disclosed |
| US-4072498-A | HERBICIDES | THE UPJOHN COMPANY (US) | 1978-02-07 | — | — | US | disclosed |