Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24288038 | 0.89 | AKR1B1 (0.41) | ACHEAKR1B1MAPK1IDO1 | |
| SCHEMBL22575141 | 0.78 | GRM1 (0.34) | ACHEAKR1B1GRM1TP53CYP3A4 | |
| SCHEMBL25768687 | 0.78 | GRM1 (0.34) | ACHEGRM1TP53CYP3A4MAPK1 | |
| SCHEMBL21606986 | 0.78 | ALK (0.34) | ACHEAKR1B1GRM1TP53CYP3A4 | |
| SCHEMBL20731174 | 0.78 | ACHE (0.38) | ACHEGRM1TP53CYP3A4MAPK1 | |
| SCHEMBL11926935 | 0.78 | ACHE (0.35) | ACHEGRM1TP53CYP3A4MAPK1 | |
| SCHEMBL18183754 | 0.77 | GRM1 (0.37) | ACHEGRM1TP53CYP3A4MAPK1 | |
| SCHEMBL19707192 | 0.76 | GRM1 (0.34) | ACHEGRM1TP53CYP3A4MAPK1 | |
| SCHEMBL30199232 | 0.76 | GRM1 (0.34) | ACHEGRM1TP53CYP3A4MAPK1 | |
| SCHEMBL13336013 | 0.74 | GRM1 (0.32) | ACHEGRM1TP53CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5068333-A | 6-chloro-3,4-dihydro-pyrano [2,3-b]pyridines having the R configuration | PFIZER INC. (US) | 1991-11-26 | — | — | US | disclosed |