SCHEMBL9877248

SCHEMBL9877248

CN(O)C(=O)C=Cc1cccc2ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 1/20 0.58
HDAC6 Q9UBN7 1/20 0.58
MTNR1A P48039 1/20 0.53
MTNR1B P49286 1/20 0.53
MAPT P10636 2/20 0.52
SMN1; SMN2 Q16637 2/20 0.52
ALDH1A1 P00352 1/20 0.52
CYP1A1 P04798 1/20 0.52
CYP1A2 P05177 1/20 0.52
CYP2D6 P10635 1/20 0.52
HPGD P15428 1/20 0.52
NPY1R P25929 1/20 0.52
MAPK1 P28482 1/20 0.52
NPY2R P49146 1/20 0.52
CYP1B1 Q16678 1/20 0.52
PLK1 P53350 1/20 0.50
KDM4E B2RXH2 1/20 0.49
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
SMPD2 O60906 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28379025 0.89 HDAC8 (0.59) HDAC8HDAC6MTNR1AMTNR1BMAPT
SCHEMBL15358894 0.86 HDAC8 (0.56) HDAC8HDAC6MTNR1AMTNR1BMAPT
SCHEMBL28376849 0.81 NPC1 (0.58) HDAC8HDAC6MTNR1AMTNR1BMAPT
SCHEMBL10361683 0.81 MAOB (0.56)
SCHEMBL30257366 0.80 HDAC8 (0.65) HDAC8HDAC6MTNR1AMTNR1BMAPT
SCHEMBL1866899 0.80 HDAC8 (0.65) HDAC8HDAC6MTNR1AMTNR1BMAPT
SCHEMBL1866901 0.80 HDAC8 (0.65) HDAC8HDAC6MTNR1AMTNR1BMAPT
SCHEMBL30963016 0.80 HDAC8 (0.65) HDAC8HDAC6MTNR1AMTNR1BMAPT
SCHEMBL3007219 0.79 HDAC8 (0.69) HDAC8HDAC6MTNR1AMTNR1BMAPT
SCHEMBL5598861 0.79 HDAC8 (0.69) HDAC8HDAC6MTNR1AMTNR1BMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5036157-A Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents BURROUGHS WELLCOME CO. 1991-07-30 US disclosed
US-4977188-A Hydroamic acid derivatives BURROUGHS WELLCOME CO. (US) 1990-12-11 US disclosed
WO-1990001929-A1 NEW MEDICAL USE THE WELLCOME FOUNDATION LIMITED (GB) 1990-03-08 WO disclosed
US-4738986-A CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS BURROUGHS WELLCOME CO. (US) 1988-04-19 US disclosed
EP-0199153-A2 Lipoxygenase inhibiting compounds ABBOTT LABORATORIES (US) 1986-10-29 EP disclosed
EP-0196184-A2 Aryl derivatives THE WELLCOME FOUNDATION LIMITED (GB) 1986-10-01 EP disclosed
US-4608390-A ANTIINFLAMMORY, ANTIALLERGENS, ASTHMA, PSORIASIS, ARTHRITIS ABBOTT LABORATORIES (US) 1986-08-26 US disclosed