Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | EPOR | P19235 | 4/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877323 | 1.00 | ALOX5 (0.50) | ALOX5ALOX5APPTGS1PTGS2EPOR | |
| SCHEMBL9877132 | 0.88 | ALOX5 (0.54) | ALOX5ALOX5APPTGS1PTGS2EPOR | |
| SCHEMBL9877137 | 0.88 | ALOX5 (0.54) | ALOX5ALOX5APPTGS1PTGS2EPOR | |
| SCHEMBL9877184 | 0.87 | ALOX5 (0.51) | ALOX5ALOX5APPTGS1PTGS2EPOR | |
| SCHEMBL9877185 | 0.87 | ALOX5 (0.51) | ALOX5ALOX5APPTGS1PTGS2EPOR | |
| SCHEMBL9707330 | 0.85 | ALOX5 (0.69) | ALOX5ALOX5APPTGS1PTGS2EPOR | |
| SCHEMBL9877152 | 0.82 | ALOX5 (0.45) | ALOX5ALOX5APPTGS1PTGS2EPOR | |
| SCHEMBL9877150 | 0.82 | ALOX5 (0.45) | ALOX5ALOX5APPTGS1PTGS2EPOR | |
| SCHEMBL10870994 | 0.79 | ALOX5 (0.43) | ALOX5ALOX5APPTGS1PTGS2EPOR | |
| SCHEMBL10870239 | 0.77 | ALOX5 (0.41) | ALOX5ALOX5APPTGS1PTGS2EPOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |