Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL983126 | 0.78 | MTOR (0.30) | MTOR | |
| SCHEMBL18156608 | 0.70 | SMN1; SMN2 (0.44) | SMN1; SMN2NUDT1SLC29A1PIK3CAPIK3R1 | |
| SCHEMBL13828670 | 0.69 | SMN1; SMN2 (0.46) | SMN1; SMN2NUDT1SLC29A1PIK3CAPIK3R1 | |
| SCHEMBL2708111 | 0.68 | MTOR (0.53) | SMN1; SMN2LMNAMAPTHTTMTOR | |
| SCHEMBL7930954 | 0.67 | SMN1; SMN2 (0.49) | SMN1; SMN2SLC29A1POLBLMNAMAPT | |
| SCHEMBL985479 | 0.67 | SMN1; SMN2 (0.39) | SMN1; SMN2POLBLMNAMAPTHTT | |
| SCHEMBL2708165 | 0.66 | MTOR (0.55) | SMN1; SMN2SLC29A1LMNAMAPTHTT | |
| SCHEMBL4973147 | 0.66 | SMN1; SMN2 (0.48) | SMN1; SMN2PIK3CAPIK3R1POLBLMNA | |
| SCHEMBL2707474 | 0.65 | MTOR (0.42) | SMN1; SMN2LMNAMAPTHTTMTOR | |
| SCHEMBL25391427 | 0.65 | SLC29A1 (0.41) | SMN1; SMN2SLC29A1PIK3CAPIK3R1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180139962-A1 | FUNGICIDAL N-CYCLOALKYL-N-{[ORTHO-(1-SUBSTITUTED-CYCLOALKYL)HETEROARYL]METHYL}PYRAZOLE(THIO)CARBOXAMIDS | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-05-24 | — | — | US | claimed |
| EP-3298000-A1 | FUNGICIDAL N-CYCLOALKYL-N-{[ORTHO-(1-SUBSTITUTED-CYCLOALKYL)HETEROARYL]METHYL}PYRAZOLE(THIO)CARBOXAMIDS | Bayer CropScience Aktiengesellschaft (DE) | 2018-03-28 | — | — | EP | claimed |
| WO-2016184941-A1 | FUNGICIDAL N-CYCLOALKYL-N-{[ORTHO-(1-SUBSTITUTED-CYCLOALKYL)HETEROARYL]METHYL}PYRAZOLE(THIO)CARBOXAMIDS | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-11-24 | — | — | WO | claimed |
| US-20180139962-A1 | FUNGICIDAL N-CYCLOALKYL-N-{[ORTHO-(1-SUBSTITUTED-CYCLOALKYL)HETEROARYL]METHYL}PYRAZOLE(THIO)CARBOXAMIDS | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-05-24 | — | — | US | disclosed |
| EP-3298000-A1 | FUNGICIDAL N-CYCLOALKYL-N-{[ORTHO-(1-SUBSTITUTED-CYCLOALKYL)HETEROARYL]METHYL}PYRAZOLE(THIO)CARBOXAMIDS | Bayer CropScience Aktiengesellschaft (DE) | 2018-03-28 | — | — | EP | disclosed |
| WO-2016184941-A1 | FUNGICIDAL N-CYCLOALKYL-N-{[ORTHO-(1-SUBSTITUTED-CYCLOALKYL)HETEROARYL]METHYL}PYRAZOLE(THIO)CARBOXAMIDS | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-11-24 | — | — | WO | disclosed |
| WO-2012099581-A1 | DIHYDROFUROPYRIMIDINE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-07-26 | — | — | WO | disclosed |
| US-20110021515-A1 | DIHYROFUROPYRMINDINE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021515-A1 | DIHYROFUROPYRMINDINE COMPOUNDS | MTOR, RICTOR, DEPTOR | SMN1; SMN2 3777/4885NUDT1 740/4885SLC29A1 1577/4885 |
| US-20180139962-A1 | FUNGICIDAL N-CYCLOALKYL-N-{[ORTHO-(1-SUBSTITUTED-CYCLOALKYL)HETEROARYL]METHYL}PYRAZOLE(THIO)CARBOXAMIDS | CBR3, CYP51A1, CBR1 | SMN1; SMN2 4091/4885NUDT1 599/4885SLC29A1 1170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.