Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7779615 | 0.87 | PTGIR (0.53) | PTGIRPTGS2 | |
| SCHEMBL7777316 | 0.87 | PTGS2 (0.60) | PTGIRPTGS2PTGDR2 | |
| SCHEMBL9095168 | 0.87 | PTGS2 (0.60) | PTGIRPTGS2PTGDR2 | |
| SCHEMBL10358778 | 0.86 | PTGIR (0.51) | PTGIRHSD17B10ALOX15MEN1KMT2A | |
| SCHEMBL11493472 | 0.84 | PTGIR (0.81) | PTGIRHSD17B10MEN1KMT2APTGS2 | |
| SCHEMBL11493056 | 0.83 | HSD17B10 (0.49) | PTGIRHSD17B10ALOX15MEN1KMT2A | |
| SCHEMBL11484651 | 0.83 | PTGIR (0.66) | PTGIRHSD17B10MEN1KMT2APTGS2 | |
| SCHEMBL9877233 | 0.81 | MEN1 (0.56) | PTGIRMEN1KMT2AKDM4EALDH1A1 | |
| Ethane SCHEMBL11621863 | 0.81 | HSD17B10 (0.47) | PTGIRHSD17B10ALOX15MEN1KMT2A | |
| SCHEMBL8104423 | 0.80 | PTGIR (1.00) | PTGIRHSD17B10MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988725-A | Cardiovascular disorders, antiarrhythmia agents | STERLING DRUG INC. (US) | 1991-01-29 | — | — | US | disclosed |
| EP-0388654-A2 | Azole-1-alkanamides as antiarrhythmic agents and preparation thereof | STERLING DRUG INC. (US) | 1990-09-26 | — | — | EP | disclosed |
| US-4916150-A | 1H-pyrazole-1-alkanamines antiarrhythmic compositions and use | STERLING DRUG INC. (US) | 1990-04-10 | — | — | US | disclosed |