Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | GALR3 | O60755 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 13/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 13/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 3/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877512 | 1.00 | MAPT (0.45) | MAPTGALR3SMN1; SMN2THRBPDE3B | |
| SCHEMBL9877075 | 0.83 | PDE3B (0.49) | MAPTGALR3SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL10424705 | 0.82 | PDE3B (0.44) | MAPTGALR3SMN1; SMN2THRBPDE3B | |
| SCHEMBL9878653 | 0.80 | PDE3B (0.55) | MAPTGALR3SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL9178917 | 0.78 | PDE3B (0.51) | MAPTPDE3BPDE3AALDH1A1SLFN12 | |
| Iodide SCHEMBL9878412 | 0.78 | PDE3B (0.43) | MAPTGALR3SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL10513962 | 0.78 | KDM4E (0.55) | MAPTGALR3SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL7294751 | 0.78 | PDE3B (0.50) | MAPTGALR3THRBPDE3BPDE3A | |
| SCHEMBL9877943 | 0.77 | PDE3B (0.49) | MAPTGALR3THRBPDE3BPDE3A | |
| SCHEMBL10512577 | 0.76 | KDM4E (0.47) | MAPTGALR3SMN1; SMN2PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5039675-A | Cardiovascular disorders | HEUMANN PHARMA GMBH & CO. (DE) | 1991-08-13 | — | — | US | disclosed |
| EP-0310737-A1 | Benzimidazoles, process for their preparation and medicines containing them | HEUMANN PHARMA GMBH & CO (DE) | 1989-04-12 | — | — | EP | disclosed |