Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877262 | 0.82 | KDM4E (0.48) | ALDH1A1MAPK1LMNAMEN1KMT2A | |
| Ipazilide SCHEMBL120491 | 0.77 | MAPK1 (0.51) | ALDH1A1MAPK1MEN1KMT2AGAA | |
| Ipazilide SCHEMBL120490 | 0.77 | MAPK1 (0.51) | ALDH1A1MAPK1MEN1KMT2AGAA | |
| Ipazilide SCHEMBL635854 | 0.71 | MAPK1 (0.55) | ALDH1A1MAPK1MEN1KMT2AGAA | |
| SCHEMBL9877859 | 0.71 | MEN1 (0.46) | ALDH1A1MAPK1LMNAMEN1KMT2A | |
| Ipazilide SCHEMBL9877353 | 0.70 | MAPK1 (0.54) | ALDH1A1MAPK1MEN1KMT2AGAA | |
| SCHEMBL10434561 | 0.70 | SCN1A (0.38) | ALDH1A1MAPK1SMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL10359075 | 0.70 | MEN1 (0.64) | MAPK1MEN1KMT2AGAAKDM4E | |
| Water SCHEMBL10510762 | 0.69 | MEN1 (0.63) | MAPK1MEN1KMT2AGAAKDM4E | |
| SCHEMBL10358746 | 0.68 | TP53 (0.52) | ALDH1A1MAPK1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988725-A | Cardiovascular disorders, antiarrhythmia agents | STERLING DRUG INC. (US) | 1991-01-29 | — | — | US | disclosed |
| EP-0392160-A1 | Azole-1-alkanamides as antiarrhythmic agents and preparation thereof | STERLING DRUG INC. (US) | 1990-10-17 | — | — | EP | disclosed |
| US-4962120-A | ANTIARRHYTHMIA AGENTS | STERLING DRUG INC. (US) | 1990-10-09 | — | — | US | disclosed |
| EP-0388654-A2 | Azole-1-alkanamides as antiarrhythmic agents and preparation thereof | STERLING DRUG INC. (US) | 1990-09-26 | — | — | EP | disclosed |
| US-4916150-A | 1H-pyrazole-1-alkanamines antiarrhythmic compositions and use | STERLING DRUG INC. (US) | 1990-04-10 | — | — | US | disclosed |
| US-4898880-A | N-(heterocycle)alkyl)-1H-pyrazole-1-alkanamides as antiarrhythmic agents, compositions and use | STERLING DRUG INC. (US) | 1990-02-06 | — | — | US | disclosed |