Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 2/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10359758 | 0.90 | PTGIR (0.49) | PTGIRADRB3TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL9877283 | 0.90 | PTGIR (0.51) | PTGIRADRB3TP53SMN1; SMN2RAB9A | |
| Hydrochloric Acid SCHEMBL10506008 | 0.89 | PTGIR (0.48) | PTGIRADRB3TP53SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9877683 | 0.88 | PTGIR (0.47) | PTGIRADRB3TP53ALDH1A1KMT2A | |
| Ipazilide SCHEMBL635854 | 0.88 | MAPK1 (0.55) | PTGIRTP53POLBALDH1A1KMT2A | |
| SCHEMBL10359077 | 0.88 | PTGIR (0.49) | PTGIRADRB3TP53SMN1; SMN2ALDH1A1 | |
| Ipazilide SCHEMBL9877353 | 0.87 | MAPK1 (0.54) | PTGIRTP53POLBALDH1A1KMT2A | |
| SCHEMBL9878048 | 0.87 | TP53 (0.46) | PTGIRADRB3TP53ALDH1A1KMT2A | |
| SCHEMBL9877735 | 0.87 | PTGIR (0.48) | PTGIRADRB3TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL9877410 | 0.87 | PTGIR (0.48) | PTGIRADRB3TP53ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988725-A | Cardiovascular disorders, antiarrhythmia agents | STERLING DRUG INC. (US) | 1991-01-29 | — | — | US | disclosed |
| EP-0299407-B1 | 1H-PYRAZOLE-1-ALKANAMIDES AND PREPARATION USEFUL AS ANTIARRHYTHMIC AGENTS | STERLING DRUG INC. (US) | 1990-10-24 | — | — | EP | disclosed |
| EP-0388654-A2 | Azole-1-alkanamides as antiarrhythmic agents and preparation thereof | STERLING DRUG INC. (US) | 1990-09-26 | — | — | EP | disclosed |
| US-4916150-A | 1H-pyrazole-1-alkanamines antiarrhythmic compositions and use | STERLING DRUG INC. (US) | 1990-04-10 | — | — | US | disclosed |
| US-4870095-A | 1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use | STERLING DRUG, INC. (US) | 1989-09-26 | — | — | US | disclosed |
| EP-0299407-A1 | 1H-pyrazole-1-alkanamides and preparation useful as antiarrhythmic agents | STERLING DRUG INC. (US) | 1989-01-18 | — | — | EP | disclosed |