Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TLR4 | O00206 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9510438 | 0.76 | KDM4E (0.39) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL7782098 | 0.73 | CYP2D6 (0.38) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL31517932 | 0.73 | CYP2D6 (0.38) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL172419 | 0.72 | ALDH1A1 (0.45) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL9793537 | 0.70 | ALDH1A1 (0.46) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL1871886 | 0.69 | PPM1B (0.36) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL11215812 | 0.69 | ALDH1A1 (0.41) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL7034548 | 0.68 | KDM4E (0.38) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL11822502 | 0.68 | ALDH1A1 (0.40) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL11790471 | 0.68 | ALDH1A1 (0.41) | KDM4EALDH1A1MEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994464-A | Treatment of elevated intraocular pressure and glaucoma | MERCK & CO., INC. (US) | 1991-02-19 | — | — | US | disclosed |
| US-4889856-A | INTRAOCULAR PRESSURE REDUCTION; CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1989-12-26 | — | — | US | disclosed |
| US-4814325-A | INSECTICIDES, NEMATOCIDES, ACARICIDES | FMC CORPORATION (US) | 1989-03-21 | — | — | US | disclosed |
| EP-0020173-B1 | IMIDAZOLE GUANIDINES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1983-02-09 | — | — | EP | disclosed |
| EP-0020173-A1 | Imidazole guanidines, their preparation and compositions containing them | MERCK & CO. INC. (US) | 1980-12-10 | — | — | EP | disclosed |
| US-4220654-A | Cyclic imidazole cyanoguanidines | MERCK & CO., INC. (US) | 1980-09-02 | — | — | US | disclosed |