Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9878179 | 0.88 | GALR3 (0.58) | PDE3BPDE3ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7314154 | 0.84 | PDE3B (0.55) | PDE3BPDE3ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7310488 | 0.83 | PDE3B (0.54) | PDE3BPDE3ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7320798 | 0.83 | PDE3B (0.54) | PDE3BPDE3ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7326436 | 0.80 | PDE3B (0.51) | PDE3BPDE3ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10741604 | 0.77 | PDE3B (0.77) | PDE3BPDE3ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL16157001 | 0.77 | PDE3B (0.77) | PDE3BPDE3ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7314234 | 0.77 | SMN1; SMN2 (0.66) | HDAC1PDE3BPDE3ASMN1; SMN2KDM4E | |
| SCHEMBL7350479 | 0.74 | PDE3B (0.57) | PDE3BPDE3ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7335953 | 0.74 | HRH3 (0.69) | PDE3BPDE3ASMN1; SMN2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5039675-A | Cardiovascular disorders | HEUMANN PHARMA GMBH & CO. (DE) | 1991-08-13 | — | — | US | disclosed |
| US-4957920-A | INOTROPIC | HEUMANN PHARMA GMBH & CO. (DE) | 1990-09-18 | — | — | US | disclosed |
| EP-0310737-A1 | Benzimidazoles, process for their preparation and medicines containing them | HEUMANN PHARMA GMBH & CO (DE) | 1989-04-12 | — | — | EP | disclosed |