Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GALR3 | O60755 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307747 | 0.84 | PDE3B (0.60) | PDE3BPDE3AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7320976 | 0.83 | PDE3B (0.54) | PDE3BPDE3AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11289838 | 0.82 | PDE3B (0.55) | PDE3BPDE3AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7311327 | 0.81 | PDE3B (0.52) | PDE3BPDE3AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9878030 | 0.80 | HDAC1 (0.52) | PDE3BPDE3AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7315143 | 0.79 | PDE3B (0.54) | PDE3BPDE3AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL10741604 | 0.79 | PDE3B (0.77) | PDE3BPDE3AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL16157001 | 0.79 | PDE3B (0.77) | PDE3BPDE3AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7314234 | 0.79 | SMN1; SMN2 (0.66) | PDE3BPDE3AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7350479 | 0.76 | PDE3B (0.57) | PDE3BPDE3AMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |