Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 6/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | APAF1 | O14727 | 1/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8930315 | 0.88 | MAPT (0.73) | ELANEEGFRPIM1MEN1KMT2A | |
| SCHEMBL16226264 | 0.88 | ELANE (0.73) | ELANEEGFRPIM1MEN1KMT2A | |
| SCHEMBL8947495 | 0.86 | EGFR (0.73) | ELANEEGFRPIM1MEN1KMT2A | |
| SCHEMBL26187210 | 0.83 | ELANE (0.61) | ELANEEGFRPIM1MEN1KMT2A | |
| SCHEMBL8996346 | 0.83 | EGFR (0.56) | ELANEEGFRPIM1MEN1KMT2A | |
| SCHEMBL30610014 | 0.83 | ELANE (0.61) | ELANEEGFRPIM1MEN1KMT2A | |
| SCHEMBL30040053 | 0.83 | ELANE (0.61) | ELANEEGFRPIM1MEN1KMT2A | |
| SCHEMBL15413483 | 0.83 | EGFR (0.56) | ELANEEGFRPIM1MEN1KMT2A | |
| SCHEMBL16226501 | 0.81 | ELANE (0.61) | ELANEEGFRPIM1MEN1KMT2A | |
| SCHEMBL3417492 | 0.80 | EGFR (0.76) | ELANEEGFRPIM1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5053431-A | Antitumor-anticarcinogenic agents | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-10-01 | — | — | US | disclosed |
| US-4966918-A | ANTICARCINOGENIC AGENTS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-30 | — | — | US | disclosed |
| WO-1990008759-A1 | DERIVATIVES OF CHRYSOPHANOL | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-08-09 | — | — | WO | disclosed |