Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 12/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23586251 | 0.95 | PDE10A (0.38) | PDE10A | |
| SCHEMBL9879791 | 0.80 | — | — | |
| SCHEMBL7389179 | 0.77 | TNKS (0.33) | — | |
| SCHEMBL15661120 | 0.75 | — | — | |
| SCHEMBL9384614 | 0.74 | TNKS (0.31) | — | |
| SCHEMBL11035315 | 0.74 | KDM4E (0.35) | — | |
| SCHEMBL9382612 | 0.72 | PDE10A (0.49) | PDE10A | |
| SCHEMBL30095928 | 0.72 | PDE10A (0.48) | PDE10A | |
| SCHEMBL30095835 | 0.72 | PDE10A (0.48) | PDE10A | |
| Hydrochloric Acid SCHEMBL9382876 | 0.70 | PDE10A (0.47) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994464-A | Treatment of elevated intraocular pressure and glaucoma | MERCK & CO., INC. (US) | 1991-02-19 | — | — | US | disclosed |
| US-4889856-A | INTRAOCULAR PRESSURE REDUCTION; CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1989-12-26 | — | — | US | disclosed |
| EP-0276057-A2 | Piperazinylpyrimidines as beta-adrenergic receptor blocking agents | MERCK & CO. INC. (US) | 1988-07-27 | — | — | EP | disclosed |