Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 17/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 13/20 | 0.53 |
| ▸ | PRKCA | P17252 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9882266 | 1.00 | PRKCQ (0.53) | PRKCQPRKCDPRKCAMAPTTRPV3 | |
| SCHEMBL15273789 | 0.91 | PRKCQ (0.53) | PRKCQPRKCDPRKCAMAPTTRPV3 | |
| SCHEMBL15273819 | 0.91 | PRKCQ (0.53) | PRKCQPRKCDPRKCAMAPTTRPV3 | |
| SCHEMBL17277169 | 0.90 | PRKCQ (0.52) | PRKCQPRKCDPRKCAMAPTPIM1 | |
| SCHEMBL17277170 | 0.90 | PRKCQ (0.52) | PRKCQPRKCDPRKCAMAPTPIM1 | |
| SCHEMBL9882313 | 0.90 | PRKCQ (0.51) | PRKCQPRKCDPRKCAMAPTPIM1 | |
| SCHEMBL9882268 | 0.89 | PRKCQ (0.46) | PRKCQPRKCDPRKCAMAPTPIM1 | |
| SCHEMBL15273850 | 0.88 | PRKCQ (0.50) | PRKCQPRKCDPRKCAMAPT | |
| SCHEMBL9882382 | 0.87 | PRKCQ (0.49) | PRKCQPRKCDPRKCAMAPTTRPV3 | |
| SCHEMBL9882101 | 0.86 | PRKCQ (0.53) | PRKCQPRKCDPRKCAMAPTTRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120136000-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136000-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | MAP3K20, MAP3K5, PRKACA | PRKCQ 51/4885PRKCD 144/4885PRKCA 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.