SCHEMBL9884604

SCHEMBL9884604

Cc1cc(F)c(NC(=O)c2ccnc(Cl)c2)c(C2CCN(C/C=C/c3ccc(Cl)cc3)CC2)n1

nearest known ligand 0.46

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 3/20 0.40
CCR3 P51677 1/20 0.38
DRD4 P21917 1/20 0.36
PROKR1 Q8TCW9 1/20 0.36
KMT2A Q03164 1/20 0.36
TAS1R3 Q7RTX0 2/20 0.35
TAS1R1 Q7RTX1 2/20 0.35
TAS1R2 Q8TE23 2/20 0.35
EBP Q15125 1/20 0.35
SIGMAR1 Q99720 1/20 0.35
LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1462205 0.89 MCHR1 (0.39) MCHR1CCR3PROKR1KMT2AEBP
SCHEMBL1462207 0.89 MCHR1 (0.39) MCHR1CCR3PROKR1KMT2AEBP
SCHEMBL9884600 0.87 MCHR1 (0.42) MCHR1CCR3DRD4PROKR1TAS1R3
SCHEMBL1420662 0.86 MCHR1 (0.42) MCHR1CCR3PROKR1EBPSIGMAR1
SCHEMBL1420663 0.86 MCHR1 (0.42) MCHR1CCR3PROKR1EBPSIGMAR1
SCHEMBL75693 0.85 MCHR1 (0.44) MCHR1CCR3PROKR1EBPSIGMAR1
SCHEMBL75694 0.85 MCHR1 (0.44) MCHR1CCR3PROKR1EBPSIGMAR1
SCHEMBL9884605 0.85 MCHR1 (0.40) MCHR1CCR3PROKR1KMT2AEBP
SCHEMBL1463179 0.84 MCHR1 (0.41) MCHR1CCR3PROKR1KMT2AEBP
SCHEMBL1463178 0.84 MCHR1 (0.41) MCHR1CCR3PROKR1KMT2AEBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8193362-B2 Insecticidal compounds SYNGENTA CROP PROTECTION LLC (US) 2012-06-05 US disclosed
US-20110071191-A1 INSECTICIDAL COMPOUNDS SYNGENTA CROP PROTECTION, INC. (US) 2011-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071191-A1 INSECTICIDAL COMPOUNDS CBR3, CBR1, ACHE MCHR1 351/4885CCR3 253/4885DRD4 1171/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.