Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990682 | 0.87 | MAP3K14 (0.51) | MAP3K14PIK3CATAS1R3TAS1R1ROCK2 | |
| SCHEMBL988585 | 0.77 | PIK3CA (0.51) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL990689 | 0.76 | MAP3K14 (0.50) | MAP3K14PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL989242 | 0.72 | PIK3CA (0.58) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL990683 | 0.70 | MAP3K14 (0.58) | MAP3K14NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL989112 | 0.69 | MAP3K14 (0.41) | MAP3K14 | |
| SCHEMBL988448 | 0.68 | MAP3K14 (0.56) | MAP3K14PIK3CARAB9ASMN1; SMN2 | |
| SCHEMBL1484856 | 0.68 | PIK3CA (0.44) | PIK3CAPIK3CBPIK3CDPIK3CGNPC1 | |
| SCHEMBL20861044 | 0.68 | TAS1R3 (0.63) | PIK3CAPLK1TAS1R3TAS1R1NPC1 | |
| SCHEMBL31431836 | 0.67 | MAP3K14 (0.48) | MAP3K14PIK3CAPIK3CBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |