Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.35 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.35 |
| ▸ | VEGFA | P15692 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9104246 | 0.90 | HSP90AB1 (0.46) | PIK3C3HSP90AB1ABL1KMT2AEGLN1 | |
| SCHEMBL16167733 | 0.90 | PIK3C3 (0.38) | PIK3C3HSP90AB1ABL1KMT2AEGLN1 | |
| SCHEMBL9108294 | 0.89 | ALDH1A1 (0.44) | PIK3C3HSP90AB1ABL1KMT2AEGLN1 | |
| SCHEMBL9888615 | 0.88 | PANK3 (0.41) | PIK3C3HSP90AB1ABL1KMT2AEGLN1 | |
| SCHEMBL10183169 | 0.87 | HDAC1 (0.39) | HDAC1HDAC6KMT2AEGLN1EGLN3 | |
| SCHEMBL9109647 | 0.86 | MAPT (0.43) | PIK3C3HSP90AB1KMT2AEGLN1EGLN3 | |
| SCHEMBL9108437 | 0.86 | PIK3C3 (0.42) | PIK3C3ABL1KMT2AKDM4EMEN1 | |
| SCHEMBL9106485 | 0.86 | PIK3C3 (0.38) | PIK3C3HSP90AB1ABL1KMT2AEGLN1 | |
| SCHEMBL9888733 | 0.86 | PIK3C3 (0.38) | PIK3C3HSP90AB1ABL1KMT2AEGLN1 | |
| SCHEMBL9108759 | 0.85 | NAMPT (0.49) | HSP90AB1KMT2AKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859768-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-20120142732-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142732-A1 | HETEROARYLS AND USES THEREOF | PIK3R4, PIK3C2B, PIK3R1 | PIK3C3 52/4885HDAC1 286/4885HDAC6 811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.