Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 7/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | GSK3A | P49840 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | C1R | P00736 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627198 | 0.91 | PIK3C3 (0.39) | PIK3C3ABL1MAPK14 | |
| SCHEMBL626895 | 0.85 | PIK3C3 (0.39) | PIK3C3ABL1 | |
| SCHEMBL9890040 | 0.84 | WDR5 (0.36) | GSK3B | |
| SCHEMBL9889941 | 0.82 | PIK3C3 (0.36) | PIK3C3GSK3BGSK3AAURKANUDT1 | |
| SCHEMBL9106023 | 0.80 | S1PR4 (0.35) | PIK3C3ABL1MAPK14 | |
| SCHEMBL16167587 | 0.78 | PIK3C3 (0.40) | PIK3C3NUDT1ABL1 | |
| SCHEMBL9888752 | 0.78 | USP2 (0.36) | PIK3C3ABL1 | |
| SCHEMBL9890038 | 0.77 | AGPAT2 (0.38) | PIK3C3ABL1 | |
| SCHEMBL627636 | 0.76 | ABL1 (0.47) | ABL1 | |
| SCHEMBL9888652 | 0.75 | PIK3C3 (0.39) | PIK3C3KDRFLT1FLT4ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142732-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142732-A1 | HETEROARYLS AND USES THEREOF | PIK3R4, PIK3C2B, PIK3R1 | PIK3C3 52/4885GSK3B 734/4885GSK3A 1541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.