Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.61 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.61 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.61 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.61 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.61 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.61 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | RXRA | P19793 | 7/20 | 0.51 |
| ▸ | RXRB | P28702 | 5/20 | 0.49 |
| ▸ | RXRG | P48443 | 5/20 | 0.49 |
| ▸ | APP | P05067 | 2/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3749563 | 0.88 | TSHR (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9890776 | 0.87 | PSEN1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9890676 | 0.84 | PSEN1 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9890777 | 0.83 | PSEN1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3731501 | 0.83 | FFAR1 (0.54) | PPARGRXRAPTGDR2FFAR1FFAR4 | |
| SCHEMBL9892653 | 0.82 | PSEN1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3741185 | 0.82 | PTGDR2 (0.49) | AKR1C3AKR1C2PTGDR2GCGRFFAR1 | |
| SCHEMBL3740233 | 0.82 | FFAR4 (0.57) | PPARGRXRAPTGDR2FFAR1FFAR4 | |
| SCHEMBL3736882 | 0.82 | AKR1C3 (0.49) | PPARGAKR1C3AKR1C2PTGDR2FFAR1 | |
| SCHEMBL9892655 | 0.82 | PTGDR2 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142771-A1 | BIPHENYLACETAMIDE DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-06-07 | — | — | US | disclosed |
| US-20120142771-A1 | BIPHENYLACETAMIDE DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-06-07 | — | — | US | disclosed |
| EP-2374790-A1 | BIPHENYLACETAMIDE DERIVATIVE | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2011-10-12 | — | — | EP | disclosed |
| US-20110224304-A1 | BIPHENYLACETAMIDE DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-09-15 | — | — | US | disclosed |
| US-20110224304-A1 | BIPHENYLACETAMIDE DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142771-A1 | BIPHENYLACETAMIDE DERIVATIVE | HRH3, KCNH3, BRPF3 | PSEN1 2126/4885PSEN2 1867/4885APH1B 3431/4885 |
| US-20110224304-A1 | BIPHENYLACETAMIDE DERIVATIVE | HRH3, KCNH3, BRPF3 | PSEN1 2126/4885PSEN2 1867/4885APH1B 3431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.