Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | KCNQ1 | P51787 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.53 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CNR2 | P34972 | 3/20 | 0.52 |
| ▸ | CNR1 | P21554 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9891945 | 0.95 | TRPV1 (0.56) | SMN1; SMN2HTTNPSR1RAB9AKCNQ1 | |
| SCHEMBL9891970 | 0.87 | CCNE1 (0.53) | SMN1; SMN2HTTNPSR1RAB9AKCNQ1 | |
| SCHEMBL9891973 | 0.85 | CCNE1 (0.52) | SMN1; SMN2HTTNPSR1RAB9AKCNQ1 | |
| SCHEMBL9892079 | 0.83 | CCNE1 (0.54) | SMN1; SMN2HTTNPSR1KCNQ1LMNA | |
| SCHEMBL9893102 | 0.83 | CNR2 (0.60) | SMN1; SMN2HTTNPSR1RAB9AKCNQ1 | |
| SCHEMBL9891940 | 0.80 | CNR2 (0.58) | SMN1; SMN2HTTNPSR1RAB9AKCNQ1 | |
| SCHEMBL6255773 | 0.79 | SMN1; SMN2 (0.70) | SMN1; SMN2HTTNPSR1RAB9AKCNQ1 | |
| SCHEMBL15689170 | 0.79 | ABL1 (0.74) | SMN1; SMN2HTTRAB9ALMNAMAPT | |
| SCHEMBL13285006 | 0.78 | KMT2A (0.57) | SMN1; SMN2HTTNPSR1RAB9AKCNQ1 | |
| SCHEMBL15688795 | 0.78 | SMN1; SMN2 (0.72) | SMN1; SMN2HTTNPSR1RAB9AKCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629157-B2 | Pyrrolidine compounds which modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-14 | — | — | US | disclosed |
| US-8629157-B2 | Pyrrolidine compounds which modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-14 | — | — | US | disclosed |
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | CNR2, CNR1, OPRL1 | SMN1; SMN2 4659/4885HTT 3335/4885NPSR1 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.