Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.70 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 6/20 | 0.69 |
| ▸ | ABL1 | P00519 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.64 |
| ▸ | RELA | Q04206 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15688795 | 0.99 | SMN1; SMN2 (0.72) | SMN1; SMN2MAPTLMNAHTTALOX12 | |
| SCHEMBL15689170 | 0.95 | ABL1 (0.74) | SMN1; SMN2MAPTLMNAHTTALOX12 | |
| SCHEMBL2554299 | 0.89 | ABL1 (0.67) | SMN1; SMN2MAPTLMNAHTTALOX12 | |
| SCHEMBL3339276 | 0.88 | MAPT (0.61) | SMN1; SMN2MAPTLMNAHTTALOX12 | |
| SCHEMBL17107238 | 0.86 | RAB9A (0.70) | SMN1; SMN2MAPTLMNAHTTRAB9A | |
| SCHEMBL2753301 | 0.85 | LMNA (0.71) | SMN1; SMN2MAPTLMNAHTTRAB9A | |
| SCHEMBL13257017 | 0.83 | LMNA (0.62) | SMN1; SMN2MAPTLMNAHTTALOX12 | |
| SCHEMBL10808572 | 0.82 | MEN1 (0.82) | SMN1; SMN2MAPTLMNAHTTALOX12 | |
| SCHEMBL10924496 | 0.82 | ABL1 (0.78) | SMN1; SMN2MAPTLMNAHTTALOX12 | |
| SCHEMBL14758306 | 0.81 | KDM4E (0.70) | SMN1; SMN2MAPTLMNAHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2945936-A1 | THIAZOLE DERIVATIVES AS ALPHA 7 NACHR MODULATORS | Lupin Limited (IN) | 2015-11-25 | — | — | EP | disclosed |
| US-20150299178-A1 | Thiazole Derivatives as Alpha 7 NACHR Modulators | LUPIN LIMITED (IN) | 2015-10-22 | — | — | US | disclosed |
| WO-2014072957-A1 | THIAZOLE DERIVATIVES AS ALPHA 7 NACHR MODULATORS | LUPIN LIMITED (IN) | 2014-05-15 | — | — | WO | disclosed |
| US-6900219-B2 | ABCA-1 elevating compounds | CV THERAPEUTICS, INC. (US) | 2005-05-31 | — | — | US | disclosed |
| EP-1513534-A2 | COMPOUNDS FOR INCREASING ABCA-1 EXPRESSION USEFUL FOR TREATING CORONARY ARTERY DISEASE AND ATHEROSCLEROSIS | CV THERAPEUTICS, INC. (US) | 2005-03-16 | — | — | EP | disclosed |
| US-20030220356-A1 | ABCA-1 elevating compounds | CV THERAPEUTICS, INC. | 2003-11-27 | — | — | US | disclosed |
| WO-2003084544-A2 | COMPOUNDS DOR INCREASING ABCA-1 EXPRESSION USEFUL FOR TREATING CORONARY ARTERY DISEASE AND ATHEROSCLEROSIS | CV THERAPEUTICS, INC. (US) | 2003-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220356-A1 | ABCA-1 elevating compounds | ABCD3, ABCE1, ABCB4 | SMN1; SMN2 4558/4885MAPT 4100/4885LMNA 1603/4885 |
| US-20150299178-A1 | Thiazole Derivatives as Alpha 7 NACHR Modulators | CHRNA7, CHRM1, CHRM2 | SMN1; SMN2 1298/4885MAPT 61/4885LMNA 2530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.