Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12535993 | 0.80 | PIK3CA (0.49) | PIK3CAMAP3K14NPC1MAPTRAB9A | |
| SCHEMBL1043434 | 0.78 | PIK3CA (0.63) | PIK3CAMAP3K14NPC1MAPTRAB9A | |
| SCHEMBL989303 | 0.78 | PIK3CA (0.38) | PIK3CANOTUMNPC1MAPTRAB9A | |
| SCHEMBL1043572 | 0.75 | PIK3CA (0.49) | PIK3CA | |
| SCHEMBL1484735 | 0.74 | MAP3K14 (0.40) | PIK3CAMAP3K14NOTUMNPC1MAPT | |
| SCHEMBL990975 | 0.72 | PIK3CA (0.55) | PIK3CANOTUMMAPTRAB9A | |
| SCHEMBL1484737 | 0.72 | NOTUM (0.57) | PIK3CAMAP3K14NOTUM | |
| SCHEMBL989889 | 0.71 | MAP3K14 (0.40) | PIK3CAMAP3K14NOTUMMAPTRAB9A | |
| SCHEMBL1078672 | 0.71 | PIK3CA (0.53) | PIK3CA | |
| SCHEMBL1042781 | 0.71 | PIK3CA (0.69) | PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | claimed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | claimed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |