Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989244 | 0.78 | PIK3CA (0.40) | PIK3CANOTUMMAPTNPC1RAB9A | |
| SCHEMBL1042700 | 0.72 | PIK3CA (0.42) | PIK3CANOTUMPIK3CBPIK3CGMAPT | |
| SCHEMBL988463 | 0.72 | NOTUM (0.70) | PIK3CANOTUMPIK3CB | |
| SCHEMBL989355 | 0.70 | PIK3CA (0.56) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1037814 | 0.70 | PIK3CA (0.79) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL988576 | 0.69 | NOTUM (0.56) | PIK3CANOTUMPIK3CBLMNA | |
| SCHEMBL4109996 | 0.69 | NOTUM (0.50) | PIK3CANOTUMPIK3CBMAPTLMNA | |
| SCHEMBL4109994 | 0.68 | NOTUM (0.55) | PIK3CANOTUMPIK3CBLMNA | |
| SCHEMBL12719326 | 0.68 | KDM4E (0.56) | PIK3CANOTUMPIK3CB | |
| SCHEMBL987951 | 0.68 | NOTUM (0.55) | PIK3CANOTUMPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |