Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.55 |
| ▸ | CNR2 | P34972 | 9/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26789822 | 0.90 | ALDH1A1 (0.53) | ALDH1A1MAPK14CNR2SMN1; SMN2CNR1 | |
| SCHEMBL14647382 | 0.89 | ALDH1A1 (0.51) | ALDH1A1MAPK14CNR2RAF1SMN1; SMN2 | |
| SCHEMBL11114594 | 0.88 | ALDH1A1 (0.67) | ALDH1A1MAPK14CNR2RAF1MAPK13 | |
| SCHEMBL9892942 | 0.86 | CNR2 (0.53) | ALDH1A1MAPK14CNR2SMN1; SMN2CNR1 | |
| SCHEMBL4442892 | 0.86 | ALDH1A1 (0.65) | ALDH1A1MAPK14CNR2RAF1SMN1; SMN2 | |
| SCHEMBL9892898 | 0.86 | EPHX2 (0.50) | ALDH1A1MAPK14CNR2SMN1; SMN2CNR1 | |
| SCHEMBL20458272 | 0.86 | ALDH1A1 (0.63) | ALDH1A1MAPK14CNR2RAF1SMN1; SMN2 | |
| SCHEMBL12566533 | 0.85 | ALDH1A1 (0.48) | ALDH1A1MAPK14CNR2RAF1SMN1; SMN2 | |
| SCHEMBL9892893 | 0.83 | CNR2 (0.55) | ALDH1A1MAPK14CNR2RAF1SMN1; SMN2 | |
| SCHEMBL9893018 | 0.81 | ALDH1A1 (0.71) | ALDH1A1MAPK14CNR2RAF1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443107-B1 | AZETIDINE 2 -CARBOXAMIDE DERIVATIVES WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INT (DE) | 2018-08-08 | — | — | EP | disclosed |
| US-8383615-B2 | Azetidine 2-carboxamide derivatives which modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-02-26 | — | — | US | disclosed |
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
| US-20120142666-A1 | Azetidine 2-Carboxamide Derivatives Which Modulate The CB2 Receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
| WO-2009105509-A1 | AMINE AND ETHER COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142666-A1 | Azetidine 2-Carboxamide Derivatives Which Modulate The CB2 Receptor | CNR2, CNR1, OPRL1 | ALDH1A1 1724/4885MAPK14 1715/4885CNR2 1/4885 |
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | CNR2, CNR1, OPRL1 | ALDH1A1 3279/4885MAPK14 1949/4885CNR2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.