Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 8/20 | 0.72 |
| ▸ | MARS1 | P56192 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9894206 | 0.94 | MDM2 (0.83) | MDM2MARS1PIN1AKR1C2AKR1C1 | |
| SCHEMBL1437064 | 0.94 | MDM2 (0.82) | MDM2PIN1ALDH1A1GABRA2GABRB2 | |
| SCHEMBL27862924 | 0.91 | MDM2 (0.66) | MDM2MARS1KMOGABRA2GABRB2 | |
| SCHEMBL9893643 | 0.90 | MDM2 (0.88) | MDM2PIN1AKR1C2AKR1C1KMO | |
| SCHEMBL27879117 | 0.89 | MDM2 (0.72) | MDM2PIN1GABRA2GABRB2EGFR | |
| SCHEMBL9894045 | 0.89 | MDM2 (0.82) | MDM2MARS1PIN1KMOGABRA2 | |
| SCHEMBL9893935 | 0.88 | MDM2 (0.56) | MDM2GABRA2GABRB2 | |
| SCHEMBL9893637 | 0.87 | MDM2 (0.84) | MDM2PIN1AKR1C2AKR1C1KMO | |
| SCHEMBL27862925 | 0.86 | MDM2 (0.65) | MDM2MARS1KMO | |
| SCHEMBL27879166 | 0.85 | MDM2 (0.69) | MDM2MARS1KMOGABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149661-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | NOVARTIS AG (CH) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149661-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | MDM4, MDM2, TP53 | MDM2 2/4885MARS1 418/4885PIN1 844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.