Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 7/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MARS1 | P56192 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27862924 | 0.93 | MDM2 (0.66) | MDM2SMN1; SMN2MARS1GABRA2GABRB2 | |
| SCHEMBL9893692 | 0.93 | MDM2 (0.68) | MDM2SMN1; SMN2MARS1TP53POLB | |
| SCHEMBL9894206 | 0.92 | MDM2 (0.83) | MDM2SMN1; SMN2MARS1TP53POLB | |
| SCHEMBL9894045 | 0.91 | MDM2 (0.82) | MDM2MARS1GABRA2GABRB2KMO | |
| SCHEMBL27879169 | 0.89 | MDM2 (0.69) | MDM2SMN1; SMN2MARS1TP53KMO | |
| SCHEMBL9893866 | 0.88 | MDM2 (0.62) | MDM2SMN1; SMN2MARS1TP53POLB | |
| SCHEMBL1436973 | 0.88 | MDM2 (0.89) | MDM2SMN1; SMN2TP53POLBGABRA2 | |
| SCHEMBL1437240 | 0.86 | MDM2 (0.59) | MDM2SMN1; SMN2MARS1TP53POLB | |
| SCHEMBL9893785 | 0.85 | MDM2 (0.72) | MDM2MARS1GABRA2GABRB2KMO | |
| SCHEMBL28796347 | 0.85 | MDM2 (0.88) | MDM2KMOLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102574785-A | Tetra-substituted heteroaryl compounds and their use as MDM2 and/or MDM4 modulators | NOVARTIS AG | 2012-07-11 | — | — | CN | disclosed |