Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 2/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1437191 | 0.93 | MDM2 (0.62) | MDM2GABRA2GABRB2MAPTALDH1A1 | |
| SCHEMBL1437622 | 0.91 | GABRA2 (0.52) | MDM2GABRA2GABRB2MAPTNPSR1 | |
| SCHEMBL9893880 | 0.90 | MDM2 (0.48) | MDM2GABRA2GABRB2MAPTNPSR1 | |
| SCHEMBL1437751 | 0.90 | MDM2 (0.49) | MDM2GABRA2GABRB2MAPTALDH1A1 | |
| SCHEMBL9893718 | 0.87 | MDM2 (0.45) | MDM2GABRA2GABRB2MAPTALDH1A1 | |
| SCHEMBL9893892 | 0.86 | MDM2 (0.78) | MDM2GABRA2GABRB2MAPTALDH1A1 | |
| SCHEMBL9894131 | 0.85 | MDM2 (0.46) | MDM2GABRA2GABRB2MAPTALDH1A1 | |
| SCHEMBL1443586 | 0.84 | GABRA2 (0.61) | MDM2GABRA2GABRB2MAPTALDH1A1 | |
| SCHEMBL1437126 | 0.83 | MDM2 (0.51) | MDM2GABRA2GABRB2MAPTALDH1A1 | |
| SCHEMBL9893706 | 0.83 | MAPT (0.45) | MDM2GABRA2GABRB2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149661-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | NOVARTIS AG (CH) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149661-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | MDM4, MDM2, TP53 | MDM2 2/4885GABRA2 4293/4885GABRB2 4278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.