Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.64 |
| ▸ | PIK3CB | P42338 | 16/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.64 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1039094 | 0.87 | PIK3CA (0.61) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL15663282 | 0.85 | PIK3CA (0.49) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL15663271 | 0.81 | PIK3CA (0.62) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL989383 | 0.78 | PIK3CA (1.00) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1620374 | 0.78 | PIK3CA (0.45) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1040757 | 0.76 | PIK3CA (0.53) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL15663274 | 0.76 | PIK3CA (0.49) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL990167 | 0.76 | PIK3CA (0.70) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL15663311 | 0.75 | PIK3CA (0.42) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL15663273 | 0.75 | PIK3CA (0.65) | PIK3CAPIK3CBPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-B1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH INC (US) | 2014-05-07 | — | — | EP | claimed |
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | claimed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | claimed |