Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 7/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992266 | 0.95 | L3MBTL1 (0.46) | GRM5L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL2818567 | 0.86 | L3MBTL1 (0.47) | GRM5L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL990869 | 0.85 | GRM5 (0.48) | GRM5L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL990340 | 0.85 | L3MBTL1 (0.59) | GRM5L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL990083 | 0.85 | L3MBTL1 (0.47) | GRM5L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL990807 | 0.84 | GRM5 (0.52) | GRM5L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL3284072 | 0.83 | GRM5 (0.57) | GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL990125 | 0.83 | GRM5 (0.57) | GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL991458 | 0.83 | L3MBTL1 (0.45) | KDM4EXBP1GRM5L3MBTL1NPC1 | |
| SCHEMBL3432735 | 0.83 | L3MBTL1 (0.45) | KDM4EXBP1GRM5L3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137206-A1 | PREDICTIVE MARKERS USEFUL IN THE TREATMENT OF FRAGILE X SYNDROME (FXS) | NOVARTIS AG (CH) | 2011-11-03 | — | — | WO | disclosed |
| EP-2320892-A2 | COMBINATION PRODUCTS | Novartis AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| EP-2272509-A1 | New Uses of metabotropic glutamate receptors | Novartis AG (CH) | 2011-01-12 | — | — | EP | disclosed |