Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.56 |
| ▸ | GRM5 | P41594 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.50 |
| ▸ | KDM6B | O15054 | 1/20 | 0.50 |
| ▸ | KDM5C | P41229 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.50 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL475480 | 0.97 | AXL (0.56) | AXLGRM5TSHRKDM4EKAT6A | |
| SCHEMBL5562975 | 0.90 | GRM5 (0.64) | AXLGRM5TSHRKDM4EKAT6A | |
| SCHEMBL4542026 | 0.90 | AXL (0.51) | AXLGRM5TSHRKDM4EKAT6A | |
| SCHEMBL3556217 | 0.90 | AXL (0.51) | AXLGRM5TSHRKDM4EKAT6A | |
| SCHEMBL11998005 | 0.87 | AXL (0.49) | AXLGRM5TSHRKDM4EKAT6A | |
| SCHEMBL3554650 | 0.87 | AXL (0.52) | AXLGRM5TSHRKDM4EKAT6A | |
| SCHEMBL6259 | 0.85 | TGFBR1 (0.60) | AXLTSHRKDM4ETGFBR1POLB | |
| SCHEMBL30772298 | 0.85 | TGFBR1 (0.60) | AXLTSHRKDM4ETGFBR1POLB | |
| SCHEMBL4648454 | 0.85 | KAT6A (0.47) | AXLGRM5TSHRKDM4EKAT6A | |
| SCHEMBL15173149 | 0.84 | KDM4E (0.56) | AXLGRM5TSHRKDM4EKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013117870-A1 | METHODS AND COMPOSITIONS FOR TREATING CANCER | ALMETIS (FR) | 2013-08-15 | — | — | WO | disclosed |
| US-20120329767-A1 | Methods and Compositions for Treating Cancer | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2012-12-27 | — | — | US | disclosed |
| EP-2448588-A1 | METHODS AND COMPOSITIONS FOR TREATING CANCER | Université de Strasbourg (FR) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011001109-A1 | METHODS AND COMPOSITIONS FOR TREATING CANCER | UNIVERSITE DE STRASBOURG (FR) | 2011-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329767-A1 | Methods and Compositions for Treating Cancer | TP53, VHL, HCCS | AXL 4160/4885GRM5 1645/4885TSHR 4558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.