Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | CCRL2 | O00421 | 4/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9896805 | 1.00 | PDE2A (0.34) | PDE2ACCRL2CNR1CNR2CRHR1 | |
| SCHEMBL9897416 | 1.00 | PDE2A (0.34) | PDE2ACCRL2CNR1CNR2CRHR1 | |
| SCHEMBL9897330 | 0.95 | PDE2A (0.34) | PDE2ACCRL2CNR1CNR2CRHR1 | |
| SCHEMBL9897991 | 0.95 | PDE2A (0.34) | PDE2ACCRL2CNR1CNR2CRHR1 | |
| SCHEMBL9897331 | 0.95 | PDE2A (0.34) | PDE2ACCRL2CNR1CNR2CRHR1 | |
| SCHEMBL9898462 | 0.95 | PDE2A (0.34) | PDE2ACCRL2CNR1CNR2CRHR1 | |
| SCHEMBL9897725 | 0.95 | PDE2A (0.34) | PDE2ACCRL2CNR1CNR2CRHR1 | |
| SCHEMBL9897632 | 0.94 | CCRL2 (0.36) | CCRL2CNR1CNR2CRHR1PTGER1 | |
| SCHEMBL9897903 | 0.94 | CCRL2 (0.36) | CCRL2CNR1CNR2CRHR1PTGER1 | |
| SCHEMBL9897631 | 0.94 | CCRL2 (0.36) | CCRL2CNR1CNR2CRHR1PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376442-B2 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| US-20150073001-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | ASTRAZENECA AB (SE) | 2015-03-12 | — | — | US | disclosed |
| US-8927557-B2 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2015-01-06 | — | — | US | disclosed |
| EP-2470536-B1 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2014-11-12 | — | — | EP | disclosed |
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE12, PDE4A | PDE2A 5/4885CCRL2 3936/4885CNR1 3069/4885 |
| US-20150073001-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | PDE12, PDE5A, PDE4A | PDE2A 7/4885CCRL2 2713/4885CNR1 3001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.