Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.40 |
| ▸ | CDK9 | P50750 | 3/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9895631 | 0.96 | BRD4 (0.42) | USP30PARP1CCNT1CDK9BRD4 | |
| SCHEMBL9895598 | 0.95 | USP30 (0.46) | USP30PARP1DGAT2SCN9ARIPK1 | |
| SCHEMBL9897737 | 0.91 | CCNT1 (0.39) | USP30DGAT2CCNT1CDK9SCN9A | |
| SCHEMBL9898317 | 0.91 | MEN1 (0.42) | USP30PARP1 | |
| SCHEMBL9896609 | 0.91 | HSD17B10 (0.41) | USP30PARP1BRD4 | |
| SCHEMBL9898099 | 0.91 | OPRL1 (0.40) | CCNT1CDK9BRD4 | |
| SCHEMBL16224002 | 0.91 | MEN1 (0.38) | USP30CCNT1CDK9BRD4 | |
| SCHEMBL9898158 | 0.90 | RBP4 (0.39) | CCNT1CDK9BRD4 | |
| SCHEMBL16223945 | 0.90 | CCNT1 (0.36) | USP30CCNT1CDK9BRD4 | |
| SCHEMBL9897585 | 0.90 | CCNT1 (0.40) | CCNT1CDK9BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2012-06-14 | — | — | US | claimed |
| US-8927557-B2 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2015-01-06 | — | — | US | disclosed |
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE12, PDE4A | USP30 3041/4885PARP1 255/4885DGAT2 4409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.