⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3728159 | 0.85 | — | — | |
| SCHEMBL2218606 | 0.78 | — | — | |
| SCHEMBL2070153 | 0.73 | — | — | |
| SCHEMBL4809816 | 0.62 | — | — | |
| SCHEMBL2050958 | 0.62 | — | — | |
| Bromide SCHEMBL28296934 | 0.61 | — | — | |
| SCHEMBL2329266 | 0.61 | — | — | |
| SCHEMBL7376344 | 0.60 | — | — | |
| SCHEMBL10205055 | 0.58 | — | — | |
| SCHEMBL12550550 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020121334-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF TIPIRACIL HYDROCHLORIDE AND INTERMEDIATES THEREOF | NATCO PHARMA LIMITED (IN) | 2020-06-18 | — | — | WO | claimed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| CN-115836063-A | Cycloalkylpyrimidines as FERROPORTIN inhibitors | 全球血液疗法股份有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-109996792-B | Heterocyclic compounds having activity as modulators of muscarinic M1 and/or M4 receptors in the treatment of CNS diseases and pain | 赫普泰雅治疗有限公司 | 2023-02-17 | — | — | CN | disclosed |
| CN-114940683-B | HPK1 inhibitors and uses thereof | 轩竹(北京)医药科技有限公司 | 2023-01-17 | — | — | CN | disclosed |
| WO-2020121334-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF TIPIRACIL HYDROCHLORIDE AND INTERMEDIATES THEREOF | NATCO PHARMA LIMITED (IN) | 2020-06-18 | — | — | WO | disclosed |
| CN-108003160-B | Method for synthesizing [ a ] -cyclized indole derivative | 南京理工大学 | 2020-05-19 | — | — | CN | disclosed |
| US-8012985-B2 | parasiticides, in particularly against Plasmodium and babesia; antimalarial agents | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2011-09-06 | — | — | US | disclosed |
| EP-2275100-A2 | Compounds with anti-parasitic activity and drugs containing said compounds | Centre National de la Recherche Scientifique (CNRS) (FR) | 2011-01-19 | — | — | EP | disclosed |
| EP-2266555-A2 | Compounds with antiparasitic activity and medicines containing same | Centre National de la Recherche Scientifique (CNRS) (FR) | 2010-12-29 | — | — | EP | disclosed |
| US-5525731-A | CYCLIZATION; HALOGENATION; ALKYLATION; REDUCTION; HYDROLYSIS; DECARBOXYLATION; SELENYLATION | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1996-06-11 | — | — | US | disclosed |
| US-5446047-A | Anticancer agents | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1995-08-29 | — | — | US | disclosed |
| US-5391745-A | Cytotoxic activity towards cancer cells | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1995-02-21 | — | — | US | disclosed |
| WO-1994011376-A1 | CAMPTOTHECIN ANALOGUES AND METHODS OF PREPARATION THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-05-26 | — | — | WO | disclosed |
| US-4482557-A | 3-Substituted-2-oxo-tetrahydro-pyrrol[1,2-a]pyrimidines having digitalis-like activity | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1984-11-13 | — | — | US | disclosed |
| US-4369139-A | PREVENTION OF CEREBRAL INSUFFICIENCY | HOFFMANN-LA ROCHE INC. (US) | 1983-01-18 | — | — | US | disclosed |
| US-4367229-A | 3-Substituted-tetrahydro-pyrrolo[1,2-a]pyrimidines and pharmaceutical compositions | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1983-01-04 | — | — | US | disclosed |
| EP-0005143-B1 | 1-BENZOYL-2-PYRROLIDINONE DERIVATIVE, PROCESSES FOR ITS PREPARATION AND MEDICAMENTS CONTAINING IT | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-07-14 | — | — | EP | disclosed |
| US-4279918-A | ANTIDEPRESSANTS, STIMULANTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK G.M.B.H. (DE) | 1981-07-21 | — | — | US | disclosed |
| EP-0005143-A1 | 1-Benzoyl-2-pyrrolidinone derivative, processes for its preparation and medicaments containing it | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1979-11-14 | — | — | EP | disclosed |