Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 6/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8515057 | 0.77 | BACE1 (0.39) | HDAC4BACE1BACE2HCAR2MEN1 | |
| SCHEMBL6920938 | 0.77 | BACE1 (0.39) | HDAC4BACE1BACE2HCAR2MEN1 | |
| SCHEMBL1041580 | 0.73 | HDAC4 (0.35) | HDAC4BACE1BACE2HCAR2HCRTR1 | |
| SCHEMBL18498615 | 0.73 | HDAC4 (0.34) | HDAC4KMT2AL3MBTL1GAA | |
| SCHEMBL8515218 | 0.72 | BACE1 (0.35) | HDAC4BACE1BACE2HCAR2HCRTR1 | |
| SCHEMBL18498591 | 0.72 | HDAC4 (0.35) | HDAC4BACE1BACE2HCAR2HCRTR1 | |
| SCHEMBL8515221 | 0.72 | BACE1 (0.35) | HDAC4BACE1BACE2HCAR2HCRTR1 | |
| SCHEMBL989767 | 0.70 | BACE1 (0.38) | HDAC4BACE1BACE2ALDH1A1 | |
| SCHEMBL18498609 | 0.70 | SMN1; SMN2 (0.34) | HDAC4ALDH1A1POLB | |
| SCHEMBL15541228 | 0.66 | HDAC4 (0.41) | HDAC4HCAR2KMT2AGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009897-A1 | FUSED AMINODIHYDROPYRIMIDONE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD (JP) | 2011-01-27 | — | — | WO | disclosed |